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A standardized kudzu extract NPI-031 reduces alcohol consumption in nontreatment-seeking male heavy drinkers

2023年06月21日

While this is a small pilot study requiring additional large scale controlled studies, we are encouraged. Purified puerarin another ingredient in Kudzu root was also shown to suppress alcohol intake in the short term as well reducing withdrawal reactions in high ethanol preferring rats. There is some scientific evidence suggesting acupuncture provided by a qualified practitioner can help https://ecosoberhouse.com/ cut alcohol consumption and lessen alcohol withdrawal symptoms (11). Studies on the effectiveness of kudzu for alcoholism have shown mixed results. While some studies have shown promising results, others have found no significant difference between kudzu and a placebo. It is important to note that kudzu should not be used as a substitute for professional medical treatment for alcoholism.

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• It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product.
• However, these authors noted that there was a large dropout rate, subjects were not supervised while they completed the questionnaires, and there was only a single assessment each month.
• Nine of the ten participants had previously tried other programs to eliminate alcohol cravings and intake with little or no success.

Extracts of the kudzu plant are best known for their ability to suppress alcohol intake or alter alcohol effects by laboratory animals (Heyman et al., 1996; Keung and Vallee, 1993b; Keung, 2003; Overstreet et al., 1996; Rezvani et al., 2003; Benlhabib et al., 2004). The degree of reduction is often as high as 50% and the effects appeared within one to two days of treatment. Regardless of the actual mechanism of action, it is widely accepted that the isoflavones in kudzu are effective in reducing alcohol intake in a number of mammalian species. The study found the treatment with the kudzu extract resulted in a significant reduction in the number of beers consumed.

1 Participant Flow Through Study

Today, the most popular ways to use kudzu root are as an herbal supplement or a root tea. More recently, kudzu root has made its way to Western countries as an herbal supplement. Until the effects of kudzu can be quantified properly in a larger study, then, and a standardised product is available on the market with the THR mark, it’s not something we can recommend you take. Two hours before the first visit, we gave both sub-groups a pill – neither group knew whether they were getting the supplement or the placebo. When they visited the bar, beer, spirits and white wine were freely available.

• The present study was conducted in non treatment-seeking heavy drinkers to assess the safety and efficacy of four weeks of kudzu extract in an outpatient setting.
• Persons who responded to these advertisements were given a brief telephone screen, and invited to the laboratory for further evaluations.
• Sporadic missing data from the actiwatches were filled in from the back up daily diary data.
• From improving heart health and regulating blood sugar levels to reducing inflammation and menopausal symptoms, kudzu may be a useful addition to a healthy lifestyle.
• This was demonstrated in our previous study (Penetar et al., 2011) where pharmacokinetic parameters such as peak concentration and elimination time were not affected by kudzu.

External Triggers for Alcohol Consumption

Previous studies had shown that kudzu extracts reduced alcohol drinking in rats and hamsters. In this study, researchers tested the effect of kudzu extract on drinking kudzu extract for alcoholism by humans in a naturalistic setting. The root of the Kudzu plant has been used for centuries in Chinese medicine to treat a variety of ailments, including alcoholism.

Alcohol cravings are caused by psychological and physical factors that form triggers that tempt you to drink. Most commonly used to treat depression, St. John’s wort may also help curb the urge to drink. Dairy products in general are good sources of calcium, vitamin D, and other vitamins and minerals that you’ll need to replenish to stay healthy and fight cravings. Omega-3-rich fish like salmon and mackerel may also help improve focus and overall brain health.

• Furthermore, Duffy et al. [34] reported using multiple regression analyses, greater bitterness from 3.2 mMPROP was a significant predictor of greater ethanol intensity and less alcohol intake.
• As expected, I didn’t really feel anything after taking it until I began drinking.
• All other authors declare that they have no actual or potential conflict of interest that could inappropriately influence, or be perceived to influence, this work.
• However, it does not make people feel more drunk, or affect their physical abilities or mental agility.

Kudzu’s been used to help treat alcoholism

Declinol is blended formula developed by one of us (SK) consisting of a number of key ingredients such as Kudzu, Bitter Herbs (Gentian, Tangerine Peel) and Bupleurum and other herbals (Table 1). The primary indication of this complex and the pilot study described in this article involve Declinol’s effect in alcoholism. Because this the first report on Declinol, we are compelled to briefly review these three important ingredients role in alcoholism including both central and peripheral actions. The protein in poultry and fish helps in the production of dopamine, which can help improve your mood as you fight alcohol cravings. The fiber-rich, complex carbohydrates in whole-grain breads and foods like brown rice, quinoa, barley, and farro are digested more slowly, which help keep blood sugar levels steady. This is key to keeping cravings under control, especially when your body is used to using alcohol as a quick form of fuel.

Next, Dr. Lee contacted researchers at the Bowles Center for Alcohol Studies. He suggested that they test Kudzu to see if it would reduce alcohol consumption among their rats. Findings show that subjects who took kudzu drank an average of 1.8 beers per session, compared with the 3.5 beers consumed by those who took a placebo. To our knowledge the present pilot is the first such study in the world that has systematically evaluated this novel complex in humans.

While cirrhosis scars from excessive drinking are irreversible, quitting alcohol and leading a healthier lifestyle can help your liver heal from alcohol-related liver disease. Other supplements such as L-glutamine and milk thistle are thought to decrease cravings and aid in detoxifying the liver, respectively. There is some evidence that milk thistle aids in the regeneration of liver cells. However, these supplements have not been thoroughly substantiated with scientific research to confirm the efficacy of their actions and benefits. Nonetheless, they are safe to take and may help to alleviate some symptoms of withdrawal and cravings. Researchers bought a variety of Kudzu extracts from stores and Internet sites.